Short peptide bioregulators
Cortexin
Also known as cortexin polypeptide complex
A lyophilised polypeptide extract of animal (bovine/porcine) brain cortex used as a neuroprotective drug in Russia.
In 60 seconds
Registered in Russia and some CIS countries; evidence is mostly preclinical or Russian-language clinical reports. Limited independent safety data; as a tissue extract its composition varies by production.
- Compared Cortexin, Cerebrolysin and Actovegin in rodent models of acute and chronic brain ischaemia.
- Reported that cortexin inhibits brain caspase-8, proposed as part of its neuroprotective action.
- In cultured rat sensory neurons, Cortexin reduced high-glucose-induced neuropathic changes.
Mechanism
Cortexin contains low-molecular-weight neuropeptides, amino acids and trace elements. Proposed mechanisms include inhibition of brain proteases such as caspase-8 and neurotrophic signalling; its exact active components are not defined.
Research status
Registered in Russia and some CIS countries; evidence is mostly preclinical or Russian-language clinical reports.
Key studies
Compared Cortexin, Cerebrolysin and Actovegin in rodent models of acute and chronic brain ischaemia.
Neuroprotective action of Cortexin, Cerebrolysin and Actovegin in acute or chronic brain ischemia in rats — PLoS One, 2021 · PMID 34260655
Reported that cortexin inhibits brain caspase-8, proposed as part of its neuroprotective action.
[Peptide drug cortexin inhibits brain caspase-8] — Biomed Khim, 2017 · PMID 28251948
In cultured rat sensory neurons, Cortexin reduced high-glucose-induced neuropathic changes.
Cortexin® Ameliorates High Glucose-Induced Neuropathy in Cultured Rat Sensory Neurons — Neuroendocrinology, 2023 · PMID 37080184
Safety signals in the literature
Limited independent safety data; as a tissue extract its composition varies by production.
Legal status (South Africa)
Not registered medicines in South Africa; research use only.
Related compounds we stock
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Comparisons
Questions
What is Cortexin?
A lyophilised polypeptide extract of animal (bovine/porcine) brain cortex used as a neuroprotective drug in Russia. Cortexin contains low-molecular-weight neuropeptides, amino acids and trace elements. Proposed mechanisms include inhibition of brain proteases such as caspase-8 and neurotrophic signalling; its exact active components are not defined.
What is the research status of Cortexin?
Registered in Russia and some CIS countries; evidence is mostly preclinical or Russian-language clinical reports.
What safety signals are reported for Cortexin?
Limited independent safety data; as a tissue extract its composition varies by production.
Does Living Water Labs stock Cortexin?
Not at present. Cortexin is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered medicines in South Africa; research use only.
More in Bioregulators
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
