Cortexin vs Pinealon
Cortexin is an extract of many cortical peptides; pinealon is a single synthetic tripeptide (Glu-Asp-Arg) from the Khavinson programme.
Cortexin
A lyophilised polypeptide extract of animal (bovine/porcine) brain cortex used as a neuroprotective drug in Russia.
BEST STUDIED FOR
Bioregulators
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Pinealon
Pinealon is a synthetic tripeptide (Glu-Asp-Arg, "EDR") among the Khavinson peptide bioregulators.
BEST STUDIED FOR
Neuronal-protection models
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Side by side · to buy
Price, purity and dispatch
| Compare | Cortexin | Pinealon10mg |
|---|---|---|
| Price | — | R429 |
| Cost per mg | — | R42.9 / mg |
| Purity (Janoshik) | — | On request |
| Stock | — | Restocking |
| Dispatch | — | When restocked |
| Certificate | — | Request CoA |
| Literature | — | 2 papers → |
| Research focus | Bioregulators | Neuronal-protection models |
| Read the cited profile | Notify me |
Prices are read live from the catalogue. Cost per mg is the vial price over its stated mg. Purity is shown only where the certificate is published. Every compound is supplied for laboratory research only.
SIDE BY SIDE
| Cortexin | Pinealon | |
|---|---|---|
| The key difference | Multi-peptide brain extract | Defined synthetic tripeptide |
| Class | Bioregulators | Bioregulators |
| Mechanism | Cortexin contains low-molecular-weight neuropeptides, amino acids and trace elements. | Pinealon is a synthetic tripeptide (Glu-Asp-Arg, "EDR") among the Khavinson peptide bioregulators. |
| Status | Registered in Russia and some CIS countries; evidence is mostly preclinical or Russian-language clinical reports. | A synthetic tripeptide bioregulator; not an approved medicine. |
| Reported safety signals | Limited independent safety data; as a tissue extract its composition varies by production. | No controlled human safety data; findings are from cell and animal models. |
| A key study | Compared Cortexin, Cerebrolysin and Actovegin in rodent models of acute and chronic brain ischaemia. (PLoS One 2021, PMID 34260655) | In cell studies, Pinealon increased cell viability by suppressing free-radical levels and activating proliferation. (Rejuvenation Res 2011, PMID 21978084) |
WHEN TO RESEARCH WHICH
Cortexin for extract-based neuroprotection; pinealon for a defined-molecule model. Both are discussed here strictly as research compounds; nothing on this page is medical advice or a dosing guide.
REFERENCES (PUBMED)
- [Cortexin] Neuroprotective action of Cortexin, Cerebrolysin and Actovegin in acute or chronic brain ischemia in rats — PLoS One 2021. PMID 34260655
- [Cortexin] [Peptide drug cortexin inhibits brain caspase-8] — Biomed Khim 2017. PMID 28251948
- [Cortexin] Cortexin® Ameliorates High Glucose-Induced Neuropathy in Cultured Rat Sensory Neurons — Neuroendocrinology 2023. PMID 37080184
- [Pinealon] Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes — Rejuvenation Res 2011. PMID 21978084
- [Pinealon] EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer’s Disease — Molecules 2020. PMID 33396470
FREQUENTLY ASKED
What is the difference between Cortexin and Pinealon?
Cortexin is an extract of many cortical peptides; pinealon is a single synthetic tripeptide (Glu-Asp-Arg) from the Khavinson programme.
What is the regulatory status of Cortexin and Pinealon?
Cortexin: Registered in Russia and some CIS countries; evidence is mostly preclinical or Russian-language clinical reports. Pinealon: A synthetic tripeptide bioregulator; not an approved medicine.
What safety signals have been reported?
Cortexin: Limited independent safety data; as a tissue extract its composition varies by production. Pinealon: No controlled human safety data; findings are from cell and animal models.
Which studies is this comparison based on?
For Cortexin: “Neuroprotective action of Cortexin, Cerebrolysin and Actovegin in acute or chronic brain ischemia in rats” (PMID 34260655); “[Peptide drug cortexin inhibits brain caspase-8]” (PMID 28251948); “Cortexin® Ameliorates High Glucose-Induced Neuropathy in Cultured Rat Sensory Neurons” (PMID 37080184). For Pinealon: “Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes” (PMID 21978084); “EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer’s Disease” (PMID 33396470).
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All products supplied for research purposes only. Not for human consumption.
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