Growth-hormone secretagogues & GH-axis peptides
CJC-1295 without DAC (Mod GRF 1-29)
Also known as Mod GRF 1-29 · modified GRF (1-29) · tetrasubstituted GRF · CJC-1295 no DAC
A stabilised 29-amino-acid GHRH fragment with four amino-acid substitutions — the short-acting cousin of CJC-1295 with DAC.
In 60 seconds
GHRH(1-29) analogues were studied clinically from the 1980s (GH secretion, paediatric growth). Older GHRH(1-29) studies reported short-term tolerability; GHRH analogues are prohibited in sport.
- Measured GH responses to GHRH(1-29)-NH2 and a D-Ala2-substituted analogue in normal men across a dose range.
- Systematic substitution scans of hGHRH(1-29)-NH2 identified positions that yield potent agonists.
- Identified GHRH analogues in powders seized by Danish customs using LC-HRMS.
Mechanism
GHRH(1-29)-NH2 is the shortest fully active portion of GHRH. Substitutions at positions 2, 8, 15 and 27 protect it from enzymatic breakdown, giving a short GH pulse at the pituitary GHRH receptor rather than the days-long elevation of the DAC version.
Research status
GHRH(1-29) analogues were studied clinically from the 1980s (GH secretion, paediatric growth). The modified version circulates as a research peptide and has been found in seized doping material.
Key studies
Measured GH responses to GHRH(1-29)-NH2 and a D-Ala2-substituted analogue in normal men across a dose range.
Growth hormone responses to growth hormone-releasing hormone (1-29)-NH2 and a D-Ala2 analog in normal men — Peptides, 1985 · PMID 2866496
Systematic substitution scans of hGHRH(1-29)-NH2 identified positions that yield potent agonists.
Human growth hormone-releasing hormone hGHRH(1-29)-NH2: systematic structure-activity relationship studies — J Med Chem, 1998 · PMID 9513600
Identified GHRH analogues in powders seized by Danish customs using LC-HRMS.
Glycine-modified growth hormone secretagogues identified in seized doping material — Drug Test Anal, 2019 · PMID 30136411
A randomised study in older adults measured immune parameters after a GHRH(1-29) analogue.
Effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune system of aging men and women — J Clin Endocrinol Metab, 1997 · PMID 9360512
Safety signals in the literature
Older GHRH(1-29) studies reported short-term tolerability; GHRH analogues are prohibited in sport.
Legal status (South Africa)
Not a registered medicine for human use in South Africa unless SAHPRA-registered under its own name; growth-hormone secretagogues are prohibited in sport under the WADA list. Supplied, where we stock it, strictly for laboratory research.
Related compounds we stock
Now in the catalogue
CJC-1295 without DAC (Mod GRF 1-29) is now in our catalogue, pre-blended with Ipamorelin in one research vial. Pre-orders are 10% off until the 15 October delivery lands.
Comparisons
Questions
What is CJC-1295 without DAC (Mod GRF 1-29)?
A stabilised 29-amino-acid GHRH fragment with four amino-acid substitutions — the short-acting cousin of CJC-1295 with DAC. GHRH(1-29)-NH2 is the shortest fully active portion of GHRH. Substitutions at positions 2, 8, 15 and 27 protect it from enzymatic breakdown, giving a short GH pulse at the pituitary GHRH receptor rather than the days-long elevation of the DAC version.
What is the research status of CJC-1295 without DAC (Mod GRF 1-29)?
GHRH(1-29) analogues were studied clinically from the 1980s (GH secretion, paediatric growth). The modified version circulates as a research peptide and has been found in seized doping material.
What safety signals are reported for CJC-1295 without DAC (Mod GRF 1-29)?
Older GHRH(1-29) studies reported short-term tolerability; GHRH analogues are prohibited in sport.
Does Living Water Labs stock CJC-1295 without DAC (Mod GRF 1-29)?
Not at present. CJC-1295 without DAC (Mod GRF 1-29) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not a registered medicine for human use in South Africa unless SAHPRA-registered under its own name; growth-hormone secretagogues are prohibited in sport under the WADA list. Supplied, where we stock it, strictly for laboratory research.
More in GH secretagogues
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
