Sermorelin vs CJC-1295
Sermorelin and CJC-1295 are both GHRH analogs, so this is a within-family comparison of two ways to raise growth hormone through the GHRH receptor. The defining difference is half-life: Sermorelin mimics native GHRH with a very short action, while CJC-1295 is engineered — especially with DAC — for a much longer one.
SIDE BY SIDE
| Sermorelin | CJC-1295 | |
|---|---|---|
| Class | GHRH analog (GHRH 1-29) | GHRH analog (often DAC-modified) |
| Half-life | Very short — native-like | Long — extended, especially with DAC |
| Release pattern | Brief, more physiological pulses | Sustained baseline elevation |
| Structure | First 29 residues of native GHRH | Modified GHRH with stabilising substitutions |
| Research role | Physiological GHRH pulse research | Long-acting baseline GHRH research |
| Commonly paired with | A secretagogue such as Ipamorelin | A secretagogue such as Ipamorelin |
WHEN TO RESEARCH WHICH
Research Sermorelin when the interest is a GHRH(1-29) analog that closely reproduces native GHRH kinetics with brief, more physiological pulses. Research CJC-1295 when the interest is an extended-action GHRH analog studied for a sustained baseline, particularly in its DAC-modified form. Same receptor and family; the trade-off is native-like brevity vs engineered duration. Both are reference comparisons here.
FREQUENTLY ASKED
What is the difference between Sermorelin and CJC-1295?
Both are GHRH analogs acting at the GHRH receptor. Sermorelin is a GHRH(1-29) analog with a very short, native-like half-life, while CJC-1295 is engineered — especially with DAC — for a much longer, sustained action. The core difference is duration.
Which is longer-acting?
CJC-1295, particularly in its DAC-modified form, is the long-acting analog studied for a sustained baseline, whereas Sermorelin mimics brief native GHRH pulses. Both are for research purposes only.
Do you stock these?
Both appear here as reference comparisons within the GHRH family. Browse our GH research range for the GHRH-axis compounds currently in stock, all HPLC-verified and CoA-certified.
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All products supplied for research purposes only. Not for human consumption.