Mitochondrial & longevity research compounds
Nicotinamide Riboside (NR)
Also known as NR · Niagen · nicotinamide riboside chloride
A vitamin-B3-form NAD+ precursor that raises blood NAD+ in humans, tested in randomised trials in ageing and neurodegeneration.
In 60 seconds
Multiple randomised trials (safety, Parkinson’s, MCI, COPD, PAD); GRAS status for food use in the US. Long-term trials in overweight adults and a high-dose Parkinson’s safety trial reported it as well tolerated.
- A phase 1 trial tested whether NR is safe and raises cerebral NAD in Parkinson’s disease.
- A randomised safety trial of high-dose NR in Parkinson’s disease.
- A randomised trial assessed long-term NR safety and NAD metabolism in overweight adults.
Mechanism
NR is phosphorylated by NRK enzymes to NMN and then to NAD+. Raising NAD+ is the rationale for trials in Parkinson’s disease, cognitive impairment, COPD and peripheral artery disease.
Research status
Multiple randomised trials (safety, Parkinson’s, MCI, COPD, PAD); GRAS status for food use in the US.
Key studies
A phase 1 trial tested whether NR is safe and raises cerebral NAD in Parkinson’s disease.
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease — Cell Metab, 2022 · PMID 35235774
A randomised safety trial of high-dose NR in Parkinson’s disease.
NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson’s disease — Nat Commun, 2023 · PMID 38016950
A randomised trial assessed long-term NR safety and NAD metabolism in overweight adults.
Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults — Sci Rep, 2019 · PMID 31278280
Critically reviews the human evidence on NR supplementation.
What is really known about the effects of nicotinamide riboside supplementation in humans — Sci Adv, 2023 · PMID 37478182
Safety signals in the literature
Long-term trials in overweight adults and a high-dose Parkinson’s safety trial reported it as well tolerated.
Legal status (South Africa)
Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
Related compounds we stock
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Comparisons
Questions
What is Nicotinamide Riboside (NR)?
A vitamin-B3-form NAD+ precursor that raises blood NAD+ in humans, tested in randomised trials in ageing and neurodegeneration. NR is phosphorylated by NRK enzymes to NMN and then to NAD+. Raising NAD+ is the rationale for trials in Parkinson’s disease, cognitive impairment, COPD and peripheral artery disease.
What is the research status of Nicotinamide Riboside (NR)?
Multiple randomised trials (safety, Parkinson’s, MCI, COPD, PAD); GRAS status for food use in the US.
What safety signals are reported for Nicotinamide Riboside (NR)?
Long-term trials in overweight adults and a high-dose Parkinson’s safety trial reported it as well tolerated.
Does Living Water Labs stock Nicotinamide Riboside (NR)?
Not at present. Nicotinamide Riboside (NR) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
More in Mitochondrial & longevity
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
