Mitochondrial & longevity research compounds
Humanin
Also known as HN · HNG (S14G analogue)
A 24-amino-acid peptide encoded in the mitochondrial genome — the first mitochondrial-derived peptide described — studied for cytoprotection.
In 60 seconds
Preclinical and observational research; the S14G analogue (HNG) is a more potent research form. No human interventional safety data.
- Reviews humanin as a 24-residue factor that suppresses neuronal death from Alzheimer’s-related insults.
- Describes humanin as the first mitochondrial-derived peptide and its interactions with IGF-I.
- A systematic review of humanin’s roles in ageing and age-related disease.
Mechanism
Humanin was discovered protecting neurons from Alzheimer’s-related insults. It acts through several receptors (including a trimeric cytokine-receptor complex and FPRL1) and interacts with IGF-1 signalling; circulating levels decline with age.
Research status
Preclinical and observational research; the S14G analogue (HNG) is a more potent research form. No approved medicine.
Key studies
Reviews humanin as a 24-residue factor that suppresses neuronal death from Alzheimer’s-related insults.
Humanin: after the discovery — Mol Neurobiol, 2004 · PMID 15655255
Describes humanin as the first mitochondrial-derived peptide and its interactions with IGF-I.
Humanin: Functional Interfaces with IGF-I — Growth Horm IGF Res, 2016 · PMID 27082450
A systematic review of humanin’s roles in ageing and age-related disease.
Humanin and Its Pathophysiological Roles in Aging: A Systematic Review — Biology (Basel), 2023 · PMID 37106758
Found that macrophages clearing apoptotic cells produce humanin, which promotes inflammation resolution.
HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation — Cell Death Dis, 2025 · PMID 40877234
Safety signals in the literature
No human interventional safety data.
Legal status (South Africa)
Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
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Comparisons
Questions
What is Humanin?
A 24-amino-acid peptide encoded in the mitochondrial genome — the first mitochondrial-derived peptide described — studied for cytoprotection. Humanin was discovered protecting neurons from Alzheimer’s-related insults. It acts through several receptors (including a trimeric cytokine-receptor complex and FPRL1) and interacts with IGF-1 signalling; circulating levels decline with age.
What is the research status of Humanin?
Preclinical and observational research; the S14G analogue (HNG) is a more potent research form. No approved medicine.
What safety signals are reported for Humanin?
No human interventional safety data.
Does Living Water Labs stock Humanin?
Not at present. Humanin is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
More in Mitochondrial & longevity
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
