Mitochondrial & longevity research compounds
Urolithin A
Also known as UA · Mitopure
A gut-microbiome metabolite of ellagitannins (pomegranate, berries, nuts) that stimulates mitophagy — the recycling of damaged mitochondria.
In 60 seconds
Several randomised human trials in middle-aged and older adults and athletes; marketed as a supplement. Trials report it as well tolerated over the study periods.
- A randomised placebo-controlled trial measured muscle strength and mitochondrial biomarkers with urolithin A in middle-aged adults.
- A randomised trial in older adults measured muscle endurance and mitochondrial markers.
- A randomised trial examined urolithin A’s effect on markers of immune ageing, including T memory stem cells.
Mechanism
Only some people’s gut bacteria convert dietary ellagitannins to urolithin A. It induces mitophagy and is studied for muscle mitochondrial quality and immune ageing.
Research status
Several randomised human trials in middle-aged and older adults and athletes; marketed as a supplement.
Key studies
A randomised placebo-controlled trial measured muscle strength and mitochondrial biomarkers with urolithin A in middle-aged adults.
Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults — Cell Rep Med, 2022 · PMID 35584623
A randomised trial in older adults measured muscle endurance and mitochondrial markers.
Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial — JAMA Netw Open, 2022 · PMID 35050355
A randomised trial examined urolithin A’s effect on markers of immune ageing, including T memory stem cells.
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial — Nat Aging, 2025 · PMID 41174221
Reviews urolithin A biology, its microbial production and its mitophagy-inducing activity.
Impact of the Natural Compound Urolithin A on Health, Disease, and Aging — Trends Mol Med, 2021 · PMID 34030963
Safety signals in the literature
Trials report it as well tolerated over the study periods.
Legal status (South Africa)
Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
Related compounds we stock
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Comparisons
Questions
What is Urolithin A?
A gut-microbiome metabolite of ellagitannins (pomegranate, berries, nuts) that stimulates mitophagy — the recycling of damaged mitochondria. Only some people’s gut bacteria convert dietary ellagitannins to urolithin A. It induces mitophagy and is studied for muscle mitochondrial quality and immune ageing.
What is the research status of Urolithin A?
Several randomised human trials in middle-aged and older adults and athletes; marketed as a supplement.
What safety signals are reported for Urolithin A?
Trials report it as well tolerated over the study periods.
Does Living Water Labs stock Urolithin A?
Not at present. Urolithin A is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
More in Mitochondrial & longevity
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
