Mitochondrial & longevity research compounds
NMN (Nicotinamide Mononucleotide)
Also known as β-NMN · beta-nicotinamide mononucleotide
A direct precursor of NAD+, studied in human trials as a way to raise NAD+ levels that decline with age.
In 60 seconds
Multiple small randomised human trials (insulin sensitivity, walking speed, aerobic capacity, sleep). Trials and reviews report it as well tolerated over weeks to months; long-term human data are still limited.
- A randomised trial in prediabetic women measured muscle insulin sensitivity after NMN supplementation.
- A dose-dependent randomised trial assessed blood NAD levels, physical performance and safety of NMN in middle-aged adults.
- In older adults, 12 weeks of NMN raised blood NAD and was associated with maintained walking speed.
Mechanism
NMN is converted to NAD+ by NMNAT enzymes; NAD+ is a cofactor for energy metabolism and for sirtuins and PARPs. Raising NMN availability raises tissue NAD+ in animals, the premise of human supplementation research.
Research status
Multiple small randomised human trials (insulin sensitivity, walking speed, aerobic capacity, sleep). Regulatory status of NMN as a supplement varies by country.
Key studies
A randomised trial in prediabetic women measured muscle insulin sensitivity after NMN supplementation.
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women — Science, 2021 · PMID 33888596
A dose-dependent randomised trial assessed blood NAD levels, physical performance and safety of NMN in middle-aged adults.
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial — Geroscience, 2023 · PMID 36482258
In older adults, 12 weeks of NMN raised blood NAD and was associated with maintained walking speed.
Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study — Geroscience, 2024 · PMID 38789831
Reviews the human clinical evidence on NMN safety and effects.
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update — Adv Nutr, 2023 · PMID 37619764
Safety signals in the literature
Trials and reviews report it as well tolerated over weeks to months; long-term human data are still limited.
Legal status (South Africa)
Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
Related compounds we stock
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Comparisons
Questions
What is NMN (Nicotinamide Mononucleotide)?
A direct precursor of NAD+, studied in human trials as a way to raise NAD+ levels that decline with age. NMN is converted to NAD+ by NMNAT enzymes; NAD+ is a cofactor for energy metabolism and for sirtuins and PARPs. Raising NMN availability raises tissue NAD+ in animals, the premise of human supplementation research.
What is the research status of NMN (Nicotinamide Mononucleotide)?
Multiple small randomised human trials (insulin sensitivity, walking speed, aerobic capacity, sleep). Regulatory status of NMN as a supplement varies by country.
What safety signals are reported for NMN (Nicotinamide Mononucleotide)?
Trials and reviews report it as well tolerated over weeks to months; long-term human data are still limited.
Does Living Water Labs stock NMN (Nicotinamide Mononucleotide)?
Not at present. NMN (Nicotinamide Mononucleotide) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
More in Mitochondrial & longevity
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
