Mitochondrial & longevity research compounds
SHLP2 (Small Humanin-Like Peptide 2)
Also known as SHLP-2 · small humanin-like peptide 2
A mitochondrial-derived peptide encoded in the 16S rRNA region, studied as an insulin sensitiser and cytoprotective signal.
In 60 seconds
Preclinical and observational human biomarker studies only. No human interventional safety data.
- In mice, systemic and central SHLP2 protected against diet-induced obesity and improved insulin sensitivity via POMC neurons.
- Reviews the eight known mitochondrial-derived peptides (MOTS-c, humanin, SHLP1-6) in energy metabolism.
- In an AMD cell model, exogenous SHLP2 had protective effects on mitochondrial function.
Mechanism
SHLP2 belongs to the humanin-like peptide family. In mice it acts on hypothalamic POMC neurons to regulate energy homeostasis and improves insulin sensitivity; in cells it shows chaperone-like and anti-apoptotic activity.
Research status
Preclinical and observational human biomarker studies only.
Key studies
In mice, systemic and central SHLP2 protected against diet-induced obesity and improved insulin sensitivity via POMC neurons.
Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons — Nat Commun, 2023 · PMID 37468558
Reviews the eight known mitochondrial-derived peptides (MOTS-c, humanin, SHLP1-6) in energy metabolism.
Mitochondrial-derived peptides in energy metabolism — Am J Physiol Endocrinol Metab, 2020 · PMID 32776825
In an AMD cell model, exogenous SHLP2 had protective effects on mitochondrial function.
Characterizing the protective effects of SHLP2, a mitochondrial-derived peptide, in macular degeneration — Sci Rep, 2018 · PMID 30310092
In 125 adults, circulating MOTS-c and SHLP2 associated with android and liver fat.
Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes — Biochim Biophys Acta Gen Subj, 2021 · PMID 34419510
Safety signals in the literature
No human interventional safety data.
Legal status (South Africa)
Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
Related compounds we stock
Not stocked yet — get notified
Tell us you want SHLP2 (Small Humanin-Like Peptide 2) and we’ll email you if we add it. Requests decide what we source next.
Not stocked yet
Get notified when we add SHLP2 (Small Humanin-Like Peptide 2)
One email, only when it reaches the catalogue. Every request is counted when we choose what to stock next.
Comparisons
Questions
What is SHLP2 (Small Humanin-Like Peptide 2)?
A mitochondrial-derived peptide encoded in the 16S rRNA region, studied as an insulin sensitiser and cytoprotective signal. SHLP2 belongs to the humanin-like peptide family. In mice it acts on hypothalamic POMC neurons to regulate energy homeostasis and improves insulin sensitivity; in cells it shows chaperone-like and anti-apoptotic activity.
What is the research status of SHLP2 (Small Humanin-Like Peptide 2)?
Preclinical and observational human biomarker studies only.
What safety signals are reported for SHLP2 (Small Humanin-Like Peptide 2)?
No human interventional safety data.
Does Living Water Labs stock SHLP2 (Small Humanin-Like Peptide 2)?
Not at present. SHLP2 (Small Humanin-Like Peptide 2) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
More in Mitochondrial & longevity
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
