Nootropic & neuropeptide research compounds
Orexin-A (Hypocretin-1)
Also known as hypocretin-1 · HCRT1 · OXA
A hypothalamic neuropeptide that stabilises wakefulness; its loss causes narcolepsy type 1.
In 60 seconds
Research peptide; intranasal pilot studies in humans and animal models of cognitive dysfunction. A pilot human study found intranasal orexin A modulated sympathetic vascular tone; no long-term data.
- Reviews orexin-A/B and their two receptors in sleep–wake regulation.
- A randomised pilot study in healthy men measured sympathetic vascular tone after intranasal orexin A.
- In aged rats, intranasal orexin-A affected neuronal activation and attention.
Mechanism
Orexin-A activates OX1R and OX2R receptors, driving arousal, attention and sympathetic tone. Orexin-receptor antagonists are approved for insomnia; intranasal orexin-A is studied as a research tool.
Research status
Research peptide; intranasal pilot studies in humans and animal models of cognitive dysfunction.
Key studies
Reviews orexin-A/B and their two receptors in sleep–wake regulation.
Hypocretin/Orexin Receptor Pharmacology and Sleep Phases — Front Neurol Neurosci, 2021 · PMID 34052813
A randomised pilot study in healthy men measured sympathetic vascular tone after intranasal orexin A.
Intranasal orexin A modulates sympathetic vascular tone: a pilot study in healthy male humans — J Neurophysiol, 2022 · PMID 35044844
In aged rats, intranasal orexin-A affected neuronal activation and attention.
Effects of Intranasal Orexin-A (Hypocretin-1) Administration on Neuronal Activation, Neurochemistry, and Attention in Aged Rats — Front Aging Neurosci, 2019 · PMID 32038222
A systematic review of orexin-based approaches in narcolepsy type 1.
Treatment of Narcolepsy Type 1 With Orexin: A Systematic Review — Cureus, 2024 · PMID 39898129
Safety signals in the literature
A pilot human study found intranasal orexin A modulated sympathetic vascular tone; no long-term data.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
Related compounds we stock
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Comparisons
Questions
What is Orexin-A (Hypocretin-1)?
A hypothalamic neuropeptide that stabilises wakefulness; its loss causes narcolepsy type 1. Orexin-A activates OX1R and OX2R receptors, driving arousal, attention and sympathetic tone. Orexin-receptor antagonists are approved for insomnia; intranasal orexin-A is studied as a research tool.
What is the research status of Orexin-A (Hypocretin-1)?
Research peptide; intranasal pilot studies in humans and animal models of cognitive dysfunction.
What safety signals are reported for Orexin-A (Hypocretin-1)?
A pilot human study found intranasal orexin A modulated sympathetic vascular tone; no long-term data.
Does Living Water Labs stock Orexin-A (Hypocretin-1)?
Not at present. Orexin-A (Hypocretin-1) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
More in Nootropic & neuro
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
