Mitochondrial & longevity research compounds
Spermidine
Also known as polyamine spermidine
A natural polyamine that induces autophagy, studied as a caloric-restriction mimetic and lifespan-extending compound in animals.
In 60 seconds
Strong preclinical lifespan and cardioprotection data (mice); human evidence is mostly observational and small trials. Reviews describe a good safety record at dietary-type intakes; long-term human data are limited.
- Reviews spermidine as a caloric-restriction mimetic with anti-ageing effects across models.
- Oral spermidine extended mouse lifespan and was cardioprotective.
- Found spermidine necessary for the autophagy and longevity effects of fasting in model organisms.
Mechanism
Spermidine inhibits acetyltransferases (notably EP300), promoting autophagy; fasting-induced autophagy depends on it in model organisms. Levels decline with age.
Research status
Strong preclinical lifespan and cardioprotection data (mice); human evidence is mostly observational and small trials. Available in food-derived supplements.
Key studies
Reviews spermidine as a caloric-restriction mimetic with anti-ageing effects across models.
Spermidine in health and disease — Science, 2018 · PMID 29371440
Oral spermidine extended mouse lifespan and was cardioprotective.
Cardioprotection and lifespan extension by the natural polyamine spermidine — Nat Med, 2016 · PMID 27841876
Found spermidine necessary for the autophagy and longevity effects of fasting in model organisms.
Spermidine is essential for fasting-mediated autophagy and longevity — Nat Cell Biol, 2024 · PMID 39117797
Reviews spermidine safety, absorption and metabolism.
A comprehensive review of spermidine: Safety, health effects, absorption and metabolism, food materials evaluation, physical and chemical processing, and bioprocessing — Compr Rev Food Sci Food Saf, 2022 · PMID 35478379
Safety signals in the literature
Reviews describe a good safety record at dietary-type intakes; long-term human data are limited.
Legal status (South Africa)
Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
Related compounds we stock
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Comparisons
Questions
What is Spermidine?
A natural polyamine that induces autophagy, studied as a caloric-restriction mimetic and lifespan-extending compound in animals. Spermidine inhibits acetyltransferases (notably EP300), promoting autophagy; fasting-induced autophagy depends on it in model organisms. Levels decline with age.
What is the research status of Spermidine?
Strong preclinical lifespan and cardioprotection data (mice); human evidence is mostly observational and small trials. Available in food-derived supplements.
What safety signals are reported for Spermidine?
Reviews describe a good safety record at dietary-type intakes; long-term human data are limited.
Does Living Water Labs stock Spermidine?
Not at present. Spermidine is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
More in Mitochondrial & longevity
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
