Vilon vs Thymalin

Vilon is a synthetic dipeptide modelled on thymic peptides; thymalin is the natural extract it was derived from.

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Vilon

A synthetic dipeptide (Lys-Glu) from the Khavinson bioregulator programme, studied for immune and chromatin effects in cell and animal models.

BEST STUDIED FOR

Bioregulators

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Thymalin

A polypeptide extract of calf thymus used as an immunomodulatory drug in Russia; its active short peptides (e.g. Lys-Glu) are studied as bioregulators.

BEST STUDIED FOR

Bioregulators

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SIDE BY SIDE

	Vilon	Thymalin
The key difference	Synthetic Lys-Glu dipeptide	Thymus peptide extract
Class	Bioregulators	Bioregulators
Mechanism	Its developers report that Vilon "deheterochromatinises" aged chromatin in cultured lymphocytes and modulates gene expression (including in heart tissue and splenocyte IL-2), effects attributed to direct DNA/chromatin interaction of short peptides.	Thymalin is described as restoring T-cell function and differentiation.
Status	Cell and animal studies, almost all from one research group; no independent clinical trials.	Registered in Russia; outside that, evidence is largely from one research school and published mostly in Russian-language or niche journals.
Reported safety signals	No independent human safety data.	Long clinical use in Russia is reported by its developers; independent safety data are limited.
A key study	In lymphocytes from older people, Vilon was reported to unroll condensed (heterochromatic) chromatin in vitro. (Biogerontology 2004, PMID 15105581)	Reported that thymalin activated differentiation of human haematopoietic stem cells in vitro. (Bull Exp Biol Med 2020, PMID 33237528)

WHEN TO RESEARCH WHICH

Thymalin for extract-based research; vilon for a minimal defined sequence. Both are discussed here strictly as research compounds; nothing on this page is medical advice or a dosing guide.

REFERENCES (PUBMED)

[Vilon] Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people — Biogerontology 2004. PMID 15105581
[Vilon] Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology — Bull Exp Biol Med 2002. PMID 12360356
[Vilon] In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes — Bull Exp Biol Med 2002. PMID 12447482
[Thymalin] Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells — Bull Exp Biol Med 2020. PMID 33237528
[Thymalin] The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19 — Int J Mol Sci 2023. PMID 37686182
[Thymalin] [Geroprotective effect of thymalin and epithalamin] — Adv Gerontol 2002. PMID 12577695

FREQUENTLY ASKED

What is the difference between Vilon and Thymalin?

Vilon is a synthetic dipeptide modelled on thymic peptides; thymalin is the natural extract it was derived from.

What is the regulatory status of Vilon and Thymalin?

Vilon: Cell and animal studies, almost all from one research group; no independent clinical trials. Thymalin: Registered in Russia; outside that, evidence is largely from one research school and published mostly in Russian-language or niche journals.

What safety signals have been reported?

Vilon: No independent human safety data. Thymalin: Long clinical use in Russia is reported by its developers; independent safety data are limited.

Which studies is this comparison based on?

For Vilon: “Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people” (PMID 15105581); “Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology” (PMID 12360356); “In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes” (PMID 12447482). For Thymalin: “Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells” (PMID 33237528); “The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19” (PMID 37686182); “[Geroprotective effect of thymalin and epithalamin]” (PMID 12577695).