Livagen vs Vilon

Livagen (Lys-Glu-Asp-Ala) is studied for chromatin effects in ageing cells; vilon (Lys-Glu) for thymic immune function. Both are synthetic bioregulators.

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Livagen

A synthetic tetrapeptide bioregulator from the Khavinson programme, associated with liver tissue and studied for chromatin effects in aged lymphocytes.

BEST STUDIED FOR

Bioregulators

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Vilon

A synthetic dipeptide (Lys-Glu) from the Khavinson bioregulator programme, studied for immune and chromatin effects in cell and animal models.

BEST STUDIED FOR

Bioregulators

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SIDE BY SIDE

	Livagen	Vilon
The key difference	Liver-associated tetrapeptide	Thymus-associated dipeptide
Class	Bioregulators	Bioregulators
Mechanism	Its developers report that Livagen activates ribosomal genes and decondenses heterochromatin in lymphocytes from older people, and modulates enkephalin-degrading enzymes.	Its developers report that Vilon "deheterochromatinises" aged chromatin in cultured lymphocytes and modulates gene expression (including in heart tissue and splenocyte IL-2), effects attributed to direct DNA/chromatin interaction of short peptides.
Status	Cell and animal research from one research school; no independent clinical trials.	Cell and animal studies, almost all from one research group; no independent clinical trials.
Reported safety signals	No independent human safety data.	No independent human safety data.
A key study	Reported Livagen activated ribosomal genes and altered heterochromatin in lymphocytes from older people. (Bull Exp Biol Med 2002, PMID 12533768)	In lymphocytes from older people, Vilon was reported to unroll condensed (heterochromatic) chromatin in vitro. (Biogerontology 2004, PMID 15105581)

WHEN TO RESEARCH WHICH

Both are preclinical; livagen for chromatin research, vilon for immune research. Both are discussed here strictly as research compounds; nothing on this page is medical advice or a dosing guide.

REFERENCES (PUBMED)

[Livagen] Effects of Livagen peptide on chromatin activation in lymphocytes from old people — Bull Exp Biol Med 2002. PMID 12533768
[Livagen] Effects of short peptides on lymphocyte chromatin in senile subjects — Bull Exp Biol Med 2004. PMID 15085253
[Livagen] [Effect of new peptide bioregulators livagen and epitalon on enkephalin-degrading enzymes in human serum] — Izv Akad Nauk Ser Biol 2003. PMID 12942748
[Vilon] Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people — Biogerontology 2004. PMID 15105581
[Vilon] Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology — Bull Exp Biol Med 2002. PMID 12360356
[Vilon] In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes — Bull Exp Biol Med 2002. PMID 12447482

FREQUENTLY ASKED

What is the difference between Livagen and Vilon?

Livagen (Lys-Glu-Asp-Ala) is studied for chromatin effects in ageing cells; vilon (Lys-Glu) for thymic immune function. Both are synthetic bioregulators.

What is the regulatory status of Livagen and Vilon?

Livagen: Cell and animal research from one research school; no independent clinical trials. Vilon: Cell and animal studies, almost all from one research group; no independent clinical trials.

What safety signals have been reported?

Livagen: No independent human safety data. Vilon: No independent human safety data.

Which studies is this comparison based on?

For Livagen: “Effects of Livagen peptide on chromatin activation in lymphocytes from old people” (PMID 12533768); “Effects of short peptides on lymphocyte chromatin in senile subjects” (PMID 15085253); “[Effect of new peptide bioregulators livagen and epitalon on enkephalin-degrading enzymes in human serum]” (PMID 12942748). For Vilon: “Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people” (PMID 15105581); “Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology” (PMID 12360356); “In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes” (PMID 12447482).