Noopept vs Selank
Both are Russian-developed compounds. Noopept is studied mainly for memory and cognition; selank mainly for anxiety, with immunomodulatory effects.
Noopept
A proline-containing dipeptide nootropic developed in Russia as a piracetam analogue, whose metabolite resembles an endogenous neuropeptide.
BEST STUDIED FOR
Nootropic & neuro
Read the cited profile →
Selank
Selank is a synthetic heptapeptide analogue of the immunomodulatory peptide tuftsin.
BEST STUDIED FOR
Anxiolytic and immunomodulation models
R429View product →
Side by side · to buy
Price, purity and dispatch
| Compare | Noopept | Selank10mg |
|---|---|---|
| Price | — | R429 |
| Cost per mg | — | R42.9 / mg |
| Purity (Janoshik) | — | 99.604%HPLC, published |
| Stock | — | Restocking |
| Dispatch | — | When restocked |
| Certificate | — | View CoA → |
| Literature | — | 4 papers → |
| Research focus | Nootropic & neuro | Anxiolytic and immunomodulation models |
| Read the cited profile | Notify me |
Prices are read live from the catalogue. Cost per mg is the vial price over its stated mg. Purity is shown only where the certificate is published. Every compound is supplied for laboratory research only.
SIDE BY SIDE
| Noopept | Selank | |
|---|---|---|
| The key difference | Cognition-focused dipeptide | Anxiety-focused heptapeptide |
| Class | Nootropic & neuro | Nootropic & neuro |
| Mechanism | Noopept is metabolised to cyclo-L-prolylglycine, an endogenous cyclic dipeptide. | Selank is a synthetic heptapeptide analogue of the immunomodulatory peptide tuftsin. |
| Status | Registered as a medicine in Russia; unapproved elsewhere. It has been found as an undeclared ingredient in US "cognitive" supplements. | Registered in Russia as a nasal anxiolytic; not approved elsewhere. |
| Reported safety signals | Human data are limited to Russian clinical use; an FDA-related analysis found it among unapproved drugs in supplements, raising quality and dose concerns. | Published human data come mainly from Russian clinical studies; no large Western trials. |
| A key study | Identified noopept’s main brain metabolite as resembling the endogenous peptide cyclo-L-prolylglycine. (Eur J Drug Metab Pharmacokinet 1997, PMID 9358206) | A review of the molecular mechanisms proposed to underlie the anxiolytic-like activity of the heptapeptide Selank. (Protein Pept Lett 2018, PMID 30255741) |
WHEN TO RESEARCH WHICH
Noopept for cognitive models; selank for anxiolytic models. Both are discussed here strictly as research compounds; nothing on this page is medical advice or a dosing guide.
REFERENCES (PUBMED)
- [Noopept] The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclo-L-prolylglycine — Eur J Drug Metab Pharmacokinet 1997. PMID 9358206
- [Noopept] Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model — Behav Pharmacol 1999. PMID 10780261
- [Noopept] Five Unapproved Drugs Found in Cognitive Enhancement Supplements — Neurol Clin Pract 2021. PMID 34484905
- [Selank] Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity — Protein Pept Lett 2018. PMID 30255741
- [Selank] Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress — Behav Neurol 2017. PMID 28280289
- [Selank] Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment — Bull Exp Biol Med 2019. PMID 31625062
FREQUENTLY ASKED
What is the difference between Noopept and Selank?
Both are Russian-developed compounds. Noopept is studied mainly for memory and cognition; selank mainly for anxiety, with immunomodulatory effects.
What is the regulatory status of Noopept and Selank?
Noopept: Registered as a medicine in Russia; unapproved elsewhere. It has been found as an undeclared ingredient in US "cognitive" supplements. Selank: Registered in Russia as a nasal anxiolytic; not approved elsewhere.
What safety signals have been reported?
Noopept: Human data are limited to Russian clinical use; an FDA-related analysis found it among unapproved drugs in supplements, raising quality and dose concerns. Selank: Published human data come mainly from Russian clinical studies; no large Western trials.
Which studies is this comparison based on?
For Noopept: “The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclo-L-prolylglycine” (PMID 9358206); “Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model” (PMID 10780261); “Five Unapproved Drugs Found in Cognitive Enhancement Supplements” (PMID 34484905). For Selank: “Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity” (PMID 30255741); “Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress” (PMID 28280289); “Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment” (PMID 31625062).
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All products supplied for research purposes only. Not for human consumption.
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