DSIP vs Selank

DSIP is studied for changes in sleep structure, with a small double-blind insomnia study reporting weak effects. Selank is studied for anxiety and stress responses; any sleep effect is indirect, through calmer arousal rather than direct sleep induction.

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DSIP

A nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) isolated in 1977 from rabbit cerebral venous blood during studies of sleep.

BEST STUDIED FOR

Nootropic & neuro

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Selank

Selank is a synthetic heptapeptide analogue of the immunomodulatory peptide tuftsin.

BEST STUDIED FOR

Anxiolytic and immunomodulation models

R429View product →

Side by side · to buy

Price, purity and dispatch

Compare	DSIP	Selank10mg
Price	—	R429
Cost per mg	—	R42.9 / mg
Purity (Janoshik)	—	99.604%HPLC, published
Stock	—	Restocking
Dispatch	—	When restocked
Certificate	—	View CoA →
Literature	4 papers	4 papers →
Research focus	Nootropic & neuro	Anxiolytic and immunomodulation models
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Prices are read live from the catalogue. Cost per mg is the vial price over its stated mg. Purity is shown only where the certificate is published. Every compound is supplied for laboratory research only.

SIDE BY SIDE

	DSIP	Selank
The key difference	Sleep-architecture peptide	Anxiolytic tuftsin analogue
Class	Nootropic & neuro	Nootropic & neuro
Mechanism	DSIP was named for enhancing slow-wave (delta) EEG activity after brain infusion in rabbits.	Selank is a synthetic heptapeptide analogue of the immunomodulatory peptide tuftsin.
Status	Studied in the 1980s in small human sleep studies; no approved medicine and little modern research.	Registered in Russia as a nasal anxiolytic; not approved elsewhere.
Reported safety signals	Older small studies reported no major issues; data are too limited to characterise safety.	Published human data come mainly from Russian clinical studies; no large Western trials.
A key study	The isolation paper: a peptide enhancing delta EEG after brain infusion in rabbits, with its amino-acid sequence. (Proc Natl Acad Sci U S A 1977, PMID 265572)	A review of the molecular mechanisms proposed to underlie the anxiolytic-like activity of the heptapeptide Selank. (Protein Pept Lett 2018, PMID 30255741)

WHEN TO RESEARCH WHICH

DSIP when sleep architecture is the endpoint; Selank when stress and anxiety are. Both are discussed here strictly as research compounds; nothing on this page is medical advice or a dosing guide.

REFERENCES (PUBMED)

[DSIP] Characterization of a delta-electroencephalogram (-sleep)-inducing peptide — Proc Natl Acad Sci U S A 1977. PMID 265572
[DSIP] Delta sleep-inducing peptide (DSIP): a still unresolved riddle — J Neurochem 2006. PMID 16539679
[DSIP] DSIP in sleep disturbances — Eur Neurol 1986. PMID 3758119
[Selank] Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity — Protein Pept Lett 2018. PMID 30255741
[Selank] Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress — Behav Neurol 2017. PMID 28280289
[Selank] Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment — Bull Exp Biol Med 2019. PMID 31625062

FREQUENTLY ASKED

What is the difference between DSIP and Selank?

What is the regulatory status of DSIP and Selank?

DSIP: Studied in the 1980s in small human sleep studies; no approved medicine and little modern research. Selank: Registered in Russia as a nasal anxiolytic; not approved elsewhere.

What safety signals have been reported?

DSIP: Older small studies reported no major issues; data are too limited to characterise safety. Selank: Published human data come mainly from Russian clinical studies; no large Western trials.

Which studies is this comparison based on?

For DSIP: “Characterization of a delta-electroencephalogram (-sleep)-inducing peptide” (PMID 265572); “Delta sleep-inducing peptide (DSIP): a still unresolved riddle” (PMID 16539679); “DSIP in sleep disturbances” (PMID 3758119). For Selank: “Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity” (PMID 30255741); “Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress” (PMID 28280289); “Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment” (PMID 31625062).