Mitochondrial & longevity research compounds
Fisetin
Also known as 3,3′,4′,7-tetrahydroxyflavone
A plant flavonoid (strawberries, apples) identified as one of the most potent natural senolytics in screening studies.
In 60 seconds
Preclinical evidence is strong; human senolytic trials are in progress. Low toxicity in animal studies; human data are limited.
- Fisetin reduced senescence markers and extended health and lifespan in mice.
- Intermittent fisetin improved arterial function in old mice by reducing senescence.
- Intermittent fisetin improved physical function and reduced muscle senescence in aged mice.
Mechanism
Fisetin selectively reduces senescent cells and their inflammatory secretions (SASP) in mice; intermittent dosing improved arterial and muscle function in aged animals.
Research status
Preclinical evidence is strong; human senolytic trials are in progress. Sold as a supplement.
Key studies
Fisetin reduced senescence markers and extended health and lifespan in mice.
Fisetin is a senotherapeutic that extends health and lifespan — EBioMedicine, 2018 · PMID 30279143
Intermittent fisetin improved arterial function in old mice by reducing senescence.
Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence — Aging Cell, 2024 · PMID 38062873
Intermittent fisetin improved physical function and reduced muscle senescence in aged mice.
Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches — Aging Cell, 2025 · PMID 40437670
Reviews the evidence for fisetin as a senotherapeutic.
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases — Mech Ageing Dev, 2024 · PMID 39384074
Safety signals in the literature
Low toxicity in animal studies; human data are limited.
Legal status (South Africa)
Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
Related compounds we stock
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Comparisons
Questions
What is Fisetin?
A plant flavonoid (strawberries, apples) identified as one of the most potent natural senolytics in screening studies. Fisetin selectively reduces senescent cells and their inflammatory secretions (SASP) in mice; intermittent dosing improved arterial and muscle function in aged animals.
What is the research status of Fisetin?
Preclinical evidence is strong; human senolytic trials are in progress. Sold as a supplement.
What safety signals are reported for Fisetin?
Low toxicity in animal studies; human data are limited.
Does Living Water Labs stock Fisetin?
Not at present. Fisetin is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
More in Mitochondrial & longevity
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
