Humanin vs MOTS-c
Humanin and MOTS-c are both mitochondrial-derived peptides. Humanin is mainly studied for cell survival and neuroprotection; MOTS-c for metabolism and exercise-like effects.
Humanin
A 24-amino-acid peptide encoded in the mitochondrial genome — the first mitochondrial-derived peptide described — studied for cytoprotection.
BEST STUDIED FOR
Mitochondrial & longevity
Read the cited profile →
MOTS-c
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA.
BEST STUDIED FOR
Metabolic and exercise-mimetic models
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Side by side · to buy
Price, purity and dispatch
| Compare | Humanin | MOTS-c10 mg · more sizes |
|---|---|---|
| Price | — | fromR429 |
| Cost per mg | — | R42.9 / mg |
| Purity (Janoshik) | — | 99.229%HPLC, published |
| Stock | — | Restocking |
| Dispatch | — | When restocked |
| Certificate | — | View CoA → |
| Literature | — | 4 papers → |
| Research focus | Mitochondrial & longevity | Metabolic and exercise-mimetic models |
| Read the cited profile | Notify me |
Prices are read live from the catalogue. Cost per mg is the vial price over its stated mg. Purity is shown only where the certificate is published. Every compound is supplied for laboratory research only.
SIDE BY SIDE
| Humanin | MOTS-c | |
|---|---|---|
| The key difference | Encoded in 16S rRNA region | Encoded in 12S rRNA region |
| Class | Mitochondrial & longevity | Mitochondrial & longevity |
| Mechanism | Humanin was discovered protecting neurons from Alzheimer’s-related insults. | MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA. |
| Status | Preclinical and observational research; the S14G analogue (HNG) is a more potent research form. No approved medicine. | Investigational mitochondrial-derived peptide; not an approved medicine. |
| Reported safety signals | No human interventional safety data. | Human data are limited to early-stage work; most findings are from rodent metabolic models. |
| A key study | Reviews humanin as a 24-residue factor that suppresses neuronal death from Alzheimer’s-related insults. (Mol Neurobiol 2004, PMID 15655255) | The discovery study reporting that MOTS-c activates AMPK and improved metabolic homeostasis and insulin sensitivity in mice. (Cell Metab 2015, PMID 25738459) |
WHEN TO RESEARCH WHICH
Humanin for cytoprotection; MOTS-c for metabolic regulation. Both are discussed here strictly as research compounds; nothing on this page is medical advice or a dosing guide.
REFERENCES (PUBMED)
- [Humanin] Humanin: after the discovery — Mol Neurobiol 2004. PMID 15655255
- [Humanin] Humanin: Functional Interfaces with IGF-I — Growth Horm IGF Res 2016. PMID 27082450
- [Humanin] Humanin and Its Pathophysiological Roles in Aging: A Systematic Review — Biology (Basel) 2023. PMID 37106758
- [MOTS-c] The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance — Cell Metab 2015. PMID 25738459
- [MOTS-c] MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism — Free Radic Biol Med 2016. PMID 27216708
- [MOTS-c] MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation — Front Endocrinol (Lausanne) 2023. PMID 36761202
FREQUENTLY ASKED
What is the difference between Humanin and MOTS-c?
Humanin and MOTS-c are both mitochondrial-derived peptides. Humanin is mainly studied for cell survival and neuroprotection; MOTS-c for metabolism and exercise-like effects.
What is the regulatory status of Humanin and MOTS-c?
Humanin: Preclinical and observational research; the S14G analogue (HNG) is a more potent research form. No approved medicine. MOTS-c: Investigational mitochondrial-derived peptide; not an approved medicine.
What safety signals have been reported?
Humanin: No human interventional safety data. MOTS-c: Human data are limited to early-stage work; most findings are from rodent metabolic models.
Which studies is this comparison based on?
For Humanin: “Humanin: after the discovery” (PMID 15655255); “Humanin: Functional Interfaces with IGF-I” (PMID 27082450); “Humanin and Its Pathophysiological Roles in Aging: A Systematic Review” (PMID 37106758). For MOTS-c: “The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance” (PMID 25738459); “MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism” (PMID 27216708); “MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation” (PMID 36761202).
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All products supplied for research purposes only. Not for human consumption.
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Supplied for laboratory research only · not for human use