Mitochondrial & longevity research compounds
Irisin
Also known as FNDC5 · exercise hormone
A myokine cleaved from the muscle membrane protein FNDC5 during exercise, studied for links between exercise, metabolism, bone and the brain.
In 60 seconds
Preclinical and observational research; measurement of circulating irisin has itself been debated. No human interventional safety data.
- Reviews FNDC5/irisin biology since 2012 and the open challenges in the field.
- In Alzheimer’s models, FNDC5/irisin rescued synaptic plasticity and memory defects.
- Found circulating irisin necessary for exercise’s cognitive benefits in mice.
Mechanism
Exercise induces PGC-1α, which raises FNDC5; its cleaved extracellular portion, irisin, circulates and is reported to promote white-fat browning, bone formation and, in mouse models, synaptic plasticity and memory.
Research status
Preclinical and observational research; measurement of circulating irisin has itself been debated. No approved irisin product.
Key studies
Reviews FNDC5/irisin biology since 2012 and the open challenges in the field.
Progress and Challenges in the Biology of FNDC5 and Irisin — Endocr Rev, 2021 · PMID 33493316
In Alzheimer’s models, FNDC5/irisin rescued synaptic plasticity and memory defects.
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models — Nat Med, 2019 · PMID 30617325
Found circulating irisin necessary for exercise’s cognitive benefits in mice.
Exercise hormone irisin is a critical regulator of cognitive function — Nat Metab, 2021 · PMID 34417591
Reviews the mechanisms by which irisin may protect bone.
Irisin as an agent for protecting against osteoporosis: A review of the current mechanisms and pathways — J Adv Res, 2024 · PMID 37669714
Safety signals in the literature
No human interventional safety data.
Legal status (South Africa)
Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
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Comparisons
Questions
What is Irisin?
A myokine cleaved from the muscle membrane protein FNDC5 during exercise, studied for links between exercise, metabolism, bone and the brain. Exercise induces PGC-1α, which raises FNDC5; its cleaved extracellular portion, irisin, circulates and is reported to promote white-fat browning, bone formation and, in mouse models, synaptic plasticity and memory.
What is the research status of Irisin?
Preclinical and observational research; measurement of circulating irisin has itself been debated. No approved irisin product.
What safety signals are reported for Irisin?
No human interventional safety data.
Does Living Water Labs stock Irisin?
Not at present. Irisin is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
More in Mitochondrial & longevity
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
