Nootropic & neuropeptide research compounds
PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide)
Also known as PACAP-38 · PACAP-27
A neuropeptide of the VIP family that strongly raises cAMP, studied for neuroprotection and as a migraine trigger.
In 60 seconds
Research peptide; anti-PACAP antibodies have been trialled in migraine. Infusion provokes migraine-like attacks in susceptible people, a key finding of migraine research.
- Reviews PACAP, first isolated for stimulating cAMP in pituitary cells, and its two forms.
- Reviews PACAP-induced gene and protein changes in neuronal development and repair.
- Reviews CGRP and PACAP as vasodilatory mediators of migraine.
Mechanism
PACAP acts at PAC1, VPAC1 and VPAC2 receptors. It supports neuronal development and repair in models, and as a vasodilator it is implicated, alongside CGRP, in migraine.
Research status
Research peptide; anti-PACAP antibodies have been trialled in migraine.
Key studies
Reviews PACAP, first isolated for stimulating cAMP in pituitary cells, and its two forms.
PACAP--a multifacetted neuropeptide — Chronobiol Int, 2006 · PMID 16687279
Reviews PACAP-induced gene and protein changes in neuronal development and repair.
Review on PACAP-Induced Transcriptomic and Proteomic Changes in Neuronal Development and Repair — Int J Mol Sci, 2018 · PMID 29596316
Reviews CGRP and PACAP as vasodilatory mediators of migraine.
Shared and independent roles of CGRP and PACAP in migraine pathophysiology — J Headache Pain, 2023 · PMID 37009867
Reviews VIP and PACAP and their three receptor classes across physiology and disease.
VIP and PACAP: recent insights into their functions/roles in physiology and disease from molecular and genetic studies — Curr Opin Endocrinol Diabetes Obes, 2011 · PMID 21157320
Safety signals in the literature
Infusion provokes migraine-like attacks in susceptible people, a key finding of migraine research.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
Related compounds we stock
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Comparisons
Questions
What is PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide)?
A neuropeptide of the VIP family that strongly raises cAMP, studied for neuroprotection and as a migraine trigger. PACAP acts at PAC1, VPAC1 and VPAC2 receptors. It supports neuronal development and repair in models, and as a vasodilator it is implicated, alongside CGRP, in migraine.
What is the research status of PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide)?
Research peptide; anti-PACAP antibodies have been trialled in migraine.
What safety signals are reported for PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide)?
Infusion provokes migraine-like attacks in susceptible people, a key finding of migraine research.
Does Living Water Labs stock PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide)?
Not at present. PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
More in Nootropic & neuro
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
