Growth-hormone secretagogues & GH-axis peptides
Sermorelin
Also known as GRF 1-29 · GHRH(1-29)NH2 · Geref
Synthetic GHRH(1-29) — the shortest fully active fragment of natural growth-hormone-releasing hormone, once a registered paediatric medicine.
In 60 seconds
Formerly approved (Geref) for diagnosis and treatment of idiopathic GH deficiency in children; the branded product was withdrawn commercially. Clinical-era reviews reported it as well tolerated.
- Reviews sermorelin as the shortest synthetic GHRH peptide with full activity, used diagnostically and therapeutically in paediatric GHD.
- Describes sermorelin (GRF1-29) and PEGylation strategies to extend its short half-life.
- A 2026 review of GH-axis peptides marketed as research compounds, contrasting clinical evidence with online self-administration practices.
Mechanism
Sermorelin is identical to the first 29 amino acids of human GHRH and stimulates GH release from the anterior pituitary through the GHRH receptor, preserving the pituitary’s own pulsatile feedback.
Research status
Formerly approved (Geref) for diagnosis and treatment of idiopathic GH deficiency in children; the branded product was withdrawn commercially.
Key studies
Reviews sermorelin as the shortest synthetic GHRH peptide with full activity, used diagnostically and therapeutically in paediatric GHD.
Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency — BioDrugs, 1999 · PMID 18031173
Describes sermorelin (GRF1-29) and PEGylation strategies to extend its short half-life.
PEGylation of growth hormone-releasing hormone (GRF) analogues — Adv Drug Deliv Rev, 2003 · PMID 14499707
A 2026 review of GH-axis peptides marketed as research compounds, contrasting clinical evidence with online self-administration practices.
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration — Front Endocrinol (Lausanne), 2026 · PMID 42395176
Critically reviews the shift from anabolic steroids to peptides, including GH secretagogues, in sport.
A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review — J Sports Med Phys Fitness, 2026 · PMID 41880199
Safety signals in the literature
Clinical-era reviews reported it as well tolerated. Recent reviews flag unregulated self-administration of GH-axis peptides as a growing concern.
Legal status (South Africa)
Not a registered medicine for human use in South Africa unless SAHPRA-registered under its own name; growth-hormone secretagogues are prohibited in sport under the WADA list. Supplied, where we stock it, strictly for laboratory research.
Related compounds we stock
Not stocked yet — get notified
Tell us you want Sermorelin and we’ll email you if we add it. Requests decide what we source next.
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Comparisons
Questions
What is Sermorelin?
Synthetic GHRH(1-29) — the shortest fully active fragment of natural growth-hormone-releasing hormone, once a registered paediatric medicine. Sermorelin is identical to the first 29 amino acids of human GHRH and stimulates GH release from the anterior pituitary through the GHRH receptor, preserving the pituitary’s own pulsatile feedback.
What is the research status of Sermorelin?
Formerly approved (Geref) for diagnosis and treatment of idiopathic GH deficiency in children; the branded product was withdrawn commercially.
What safety signals are reported for Sermorelin?
Clinical-era reviews reported it as well tolerated. Recent reviews flag unregulated self-administration of GH-axis peptides as a growing concern.
Does Living Water Labs stock Sermorelin?
Not at present. Sermorelin is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not a registered medicine for human use in South Africa unless SAHPRA-registered under its own name; growth-hormone secretagogues are prohibited in sport under the WADA list. Supplied, where we stock it, strictly for laboratory research.
More in GH secretagogues
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
