5-Amino-1MQ vs MOTS-c
Both are researched for metabolic effects without acting on incretin receptors. 5-amino-1MQ blocks the enzyme NNMT; MOTS-c is a peptide encoded in mitochondrial DNA that acts partly through AMPK.
5-Amino-1MQ
A small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), studied in obesity and metabolism models.
BEST STUDIED FOR
Incretin & metabolic
Read the cited profile →
MOTS-c
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA.
BEST STUDIED FOR
Metabolic and exercise-mimetic models
R429View product →
Side by side · to buy
Price, purity and dispatch
| Compare | 5-Amino-1MQ | MOTS-c10 mg · more sizes |
|---|---|---|
| Price | — | fromR429 |
| Cost per mg | — | R42.9 / mg |
| Purity (Janoshik) | — | 99.229%HPLC, published |
| Stock | — | Restocking |
| Dispatch | — | When restocked |
| Certificate | — | View CoA → |
| Literature | — | 4 papers → |
| Research focus | Incretin & metabolic | Metabolic and exercise-mimetic models |
| Read the cited profile | Notify me |
Prices are read live from the catalogue. Cost per mg is the vial price over its stated mg. Purity is shown only where the certificate is published. Every compound is supplied for laboratory research only.
SIDE BY SIDE
| 5-Amino-1MQ | MOTS-c | |
|---|---|---|
| The key difference | NNMT enzyme inhibitor (small molecule) | Mitochondrial-derived peptide, AMPK activation |
| Class | Incretin & metabolic | Mitochondrial & longevity |
| Mechanism | NNMT methylates nicotinamide using SAM, linking cellular energy (NAD+) balance and methylation capacity. | MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA. |
| Status | Preclinical: diet-induced-obese mouse studies (alone and with diet change). No human trials published. | Investigational mitochondrial-derived peptide; not an approved medicine. |
| Reported safety signals | No human safety data. NNMT is also implicated in cancer biology, an active, separate research area. | Human data are limited to early-stage work; most findings are from rodent metabolic models. |
| A key study | In diet-induced obese mice, the NNMT inhibitor 5A1MQ was studied for body composition, liver pathology and pharmacokinetics. (Diabetes Obes Metab 2024, PMID 39161060) | The discovery study reporting that MOTS-c activates AMPK and improved metabolic homeostasis and insulin sensitivity in mice. (Cell Metab 2015, PMID 25738459) |
WHEN TO RESEARCH WHICH
Both suit metabolic-mechanism research; neither has controlled human outcome data. Both are discussed here strictly as research compounds; nothing on this page is medical advice or a dosing guide.
REFERENCES (PUBMED)
- [5-Amino-1MQ] Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction — Diabetes Obes Metab 2024. PMID 39161060
- [5-Amino-1MQ] Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice — Sci Rep 2022. PMID 35013352
- [5-Amino-1MQ] Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation — Mol Metab 2021. PMID 33453420
- [MOTS-c] The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance — Cell Metab 2015. PMID 25738459
- [MOTS-c] MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism — Free Radic Biol Med 2016. PMID 27216708
- [MOTS-c] MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation — Front Endocrinol (Lausanne) 2023. PMID 36761202
FREQUENTLY ASKED
What is the difference between 5-Amino-1MQ and MOTS-c?
Both are researched for metabolic effects without acting on incretin receptors. 5-amino-1MQ blocks the enzyme NNMT; MOTS-c is a peptide encoded in mitochondrial DNA that acts partly through AMPK.
What is the regulatory status of 5-Amino-1MQ and MOTS-c?
5-Amino-1MQ: Preclinical: diet-induced-obese mouse studies (alone and with diet change). No human trials published. MOTS-c: Investigational mitochondrial-derived peptide; not an approved medicine.
What safety signals have been reported?
5-Amino-1MQ: No human safety data. NNMT is also implicated in cancer biology, an active, separate research area. MOTS-c: Human data are limited to early-stage work; most findings are from rodent metabolic models.
Which studies is this comparison based on?
For 5-Amino-1MQ: “Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction” (PMID 39161060); “Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice” (PMID 35013352); “Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation” (PMID 33453420). For MOTS-c: “The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance” (PMID 25738459); “MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism” (PMID 27216708); “MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation” (PMID 36761202).
MORE COMPARISONS
All products supplied for research purposes only. Not for human consumption.
In stock · ships from South Africa
In stock now
Supplied for laboratory research only · not for human use